Histological Study of Action of Alcohol on Hippocampal Region of Brain and Use of “Mandukaparni” as a Brain Rejuvenator

Hippocampus” is the part of brain known to carry out functions like learning, transforming information, discrimination,etc. The activity in the Hippocampus is disrupted by alcohol intake, interacting directly with Hippocampal neurons. In present study Centella asiatica has been used as neuro-protector, which is commonly known as “Mandukaparni”. “Mandukaparni” is sour and sharp in taste, easily digestible, having cold effect, nutritive and fever curer. In the present study special emphasis has been laid to see the histo-pathology of Hippocampal sub-regions, created due alcohol intake on albino rats and efforts have been made to correlate the exhibited neural degenerations in CA1, CA2, CA3, CA4 and Dg sub-regions of Hippocampus with behavioral changes. Here effectiveness of drug has been shown on learning and memory and it is classified as Medhya rasayan.Our results reveal Centella asiatica as neuroprotective agent; it’s use with alcohol showed least degeneration in different sub-regions of Hippocampus.